PhD Opening in Bioengineering: Microfluidic in-vitro Barrier Models for Bacterial Lung and Bladder Infections

100%, Basel, fixed-term

The Bio Engineering Laboratory at the Departement of Biosystems of ETH Zurich in Basel is inviting applications for a PhD position in in Engineering of Microfluidic in-vitro Barrier Models for Bacterial Lung and Bladder Infections. We are seeking a highly motivated and enthusiastic PhD student, who will work in a highly international environment in Basel, Switzerland. In the framework of a large National Competence Center of Research (NCCR) “Antiresist” (for more information, view) involving clinicians, academic and industrial research partners across multiple disciplines, a microfluidic platform for studying bacterial lung and bladder infections and testing new antibacterial drugs is currently developed. The platform includes a microfluidic system for culturing advanced in-vitro lung and bladder barrier models (membrane-based organ-on-chip models) and for exposing those to bacteria and potential target drug compounds. A variety of analysis methods (fluorescence microscopy, mass spectroscopy, TEER, permeability assays) is used to analyze and continuously monitor barrier-layer status and viability.

Job description

The candidate will further develop a microfluidic platform designed for culturing transwell-based lung and bladder organoid models in close collaboration with infection biologists from the Biozentrum (University of Basel). Specifically, the platform will be used to (1) study mechanisms underlying bacterial infections and the emergence of antimicrobial resistance, and (2) evaluate novel treatment strategies. A key objective is to optimize the platform for translational applications that can be used for testing in clinical and industrial settings.

Profile

For this highly interdisciplinary project, a suitable candidate should have:

A solid background in microengineering, including plastic fabrication methods for microfluidics
Skills in CAD design and simulation tools (e.g., COMSOL)
Experience in cell biology, in vitro culture methods, and bioassays
Experience in confocal microscopy and associated image analysis methods

Experience with transwell-based barrier models and biology is a strong advantage, and basic knowledge of microbiological techniques, including bacterial cultures, sterile handling, and infection assays is highly appreciated. Strong communication skills, a proactive work attitude and the ability to work collaboratively across disciplines as well as fluency in English (oral and written) are important assets.

Workplace

We offer

Your job with impact: Become part of ETH Zurich, which not only supports your professional development, but also actively contributes to positive change in society
We are actively committed to a sustainable and climate-neutral university
You can expect numerous benefits, such as public transport season tickets and car sharing, a wide range of sports offered by the ASVZ, childcare and attractive pension benefits

A state-of-the art cleanroom, a broad spectrum of engineering and testing equipment, as well as cell-culture and biological facilities are available in the group. Research partners within the AntiResist consortium contribute with extensive expertise in lung and bladder systems as well as with a broad range of bacterial pathogens. They also have specific cell culture and biosafety facilities.

The position is planned for 4 years.

Working, teaching and research at ETH Zurich

We value diversity

In line with our values, ETH Zurich encourages an inclusive culture. We promote equality of opportunity, value diversity and nurture a working and learning environment in which the rights and dignity of all our staff and students are respected. Visit our Equal Opportunities and Diversity website to find out how we ensure a fair and open environment that allows everyone to grow and flourish.

Curious? So are we.

We look forward to receiving your online application including:

a CV
a short and specific motivation statement for the advertised position
complete academic transcripts
two reference letters

Please note that we exclusively accept applications submitted through our online application portal. Applications via email or postal services or incomplete application packages will not be considered.

Further information about the Bio Engineering Laboratory can be found on our website. For more information about the position, please contact - exclusively via e-mail - amanzhol kurmashev@bsse.ethz.ch.

About ETH Zürich

ETH Zurich is one of the world’s leading universities specialising in science and technology. We are renowned for our excellent education, cutting-edge fundamental research and direct transfer of new knowledge into society. Over 30,000 people from more than 120 countries find our university to be a place that promotes independent thinking and an environment that inspires excellence. Located in the heart of Europe, yet forging connections all over the world, we work together to develop solutions for the global challenges of today and tomorrow.