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Post-Doctoral Researcher - High-Throughput Lipidomics

80%-100%, Zurich, fixed-term

The Institute of Molecular Systems Biology at ETH Zurich is inviting applications for a Postdoctoral position in the laboratory of Professor Dr Nicola Zamboni.

Project background

The group of Dr Zamboni researches the function and regulation of metabolism. In particular, the group is attracted by

  • systems in which metabolism or metabolites drive phenotypic differentiation
  • problems of biomedical relevance, and
  • cases that are especially complex or technically challenging

To tackle such problems, the group is largely devoted to the development of novel approaches for metabolomics, lipidomics, and 13C metabolic flux analysis, data processing and integration. 

The Zamboni lab is tightly embedded in national initiatives on personalized health, i.e. PHRT ( It hosts the PHRT Clinical Metabolomics Analysis Center (CMAC), which aims at providing cutting-edge metabolomics and lipidomics analysis to drive clinical research. While CMAC is productively contributing to numerous projects with tens of thousands of measurements per year, the PHRT is entering its second term (2022-2025) with novel aims. To tackle emerging trends, the lab is seeking several specialists with complementary expertise and interest. In the realm of lipidomics, these activities entail achieving a finer structural characterization while preserving sample throughput, expanding the toolbox of isotopic tracing for quantification of lipid levels and fluxes, disentangling lipid metabolism and trafficking across cellular organelles.


Job description

  • contribute to the development of  innovative gas phase separation and fragmentation lipidomics methods 
  • contribute to building a full service portfolio for clinical and biomedical research.
  • conduct lipidomics MS analyses on various systems (TOFs and Orbitraps, LC and GC).
  • participate in instrument maintenance. 
  • synergize with team members, collaborators, and vendors.

Your profile

  • a doctoral degree in analytical chemistry or a related field.
  • ample experience in analytical lipidomics from sample preparation to data analysis.
  • sound knowledge of lipid chemistry and biochemistry.
  • excellent general technical skills in LC-HRMS, with hands-on experience in routine maintenance.
  • experience with performing and interpreting isotopic tracing experiments is an additional asset.

ETH Zurich

ETH Zurich is one of the world’s leading universities specialising in science and technology. We are renowned for our excellent education, cutting-edge fundamental research and direct transfer of new knowledge into society. Over 30,000 people from more than 120 countries find our university to be a place that promotes independent thinking and an environment that inspires excellence. Located in the heart of Europe, yet forging connections all over the world, we work together to develop solutions for the global challenges of today and tomorrow.
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We look forward to receiving your online application with the following documents:

  • CV
  • A motivation letter stating own visions and specifying any past experience that is aligned with the job profile
  • Name and contact of two referees

Please note that we exclusively accept applications submitted through our online application portal. Applications via email or postal services will not be considered.

Further information about the Institute of Molecular Systems Biology can be found on our website, Questions regarding the position should be directed to Dr Nicola Zamboni, email (no applications).

In line with our values, ETH Zurich encourages an inclusive culture. We promote equality of opportunity, value diversity and nurture a working and learning environment in which the rights and dignity of all our staff and students are respected. Visit our Equal Opportunities and Diversity website to find out how we ensure a fair and open environment that allows everyone to grow and flourish.

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